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Brief report| Volume 10, ISSUE 6, P542-544, November 01, 1992

Acute isopropanol ingestion: Pharmacokinetic parameters in the infant

  • K.Michael Parker
    Correspondence
    Address reprint requests to Dr Parker, Toxicology Laboratory, Oklahoma Medical Center, PO Box 26307, Oklahoma City, OK 73126.
    Affiliations
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Search for articles by this author
  • Thomas A. Lera Jr
    Affiliations
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Search for articles by this author
DOI:https://doi.org/10.1016/0735-6757(92)90179-2
Acute isopropanol ingestion: Pharmacokinetic parameters in the infant
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      Abstract

      We describe a case of isopropanol intoxication in a 2-month-old infant. The source of isopropanol and both the route and time of ingestion could be clearly identified. Serial measurements of isopropanol and acetone provided data for calculating their respective elimination half-lives. Isopropanol (half-life = 5.8 hr) clearance was similar to values reported for adults; acetone (half-life = 10.8 hr) was eliminated twice as rapidly as in adults.

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      References

        • Litovitz TG
        • Bailey KM
        • Schmitz BF
        • et al.
        1990 Annual Report of the American Association of Poison Control Centers National Data Collection System.
        Am J Emerg Med. 1991; 9: 461-509
        • Senz EH
        • Goldfarb DL
        Coma in a child following use of isopropanol alcohol in sponging.
        J Pediatr. 1958; 53: 322-323
        • Lacouture MS
        • Wason S
        • Abrams A
        • et al.
        Acute isopropyl alcohol intoxication—Diagnosis and management.
        Am J Med. 1983; 75: 680-686
        • Daniel DR
        • McAnalley BH
        • Garriott JC
        Isopropyl alcohol metabolism after acute intoxication in humans.
        J Anal Toxicol. 1981; 5: 110-112
        • Natowicz M
        • Donahue J
        • Gorman L
        • et al.
        Pharmacokinetic analysis of a case of isopropanol intoxication.
        Clin Chem. 1985; 31: 326-328
        • Gaudet MP
        • Fraser GL
        Isopropanol ingestion: Case report with pharmacokinetic analysis.
        Am J Emerg Med. 1989; 7: 297-299
        • Pappas AA
        • Ackerman BH
        • Olsen KM
        • et al.
        Isopropanol ingestion: A report of six episodes with isopropanol and acetone serum concentration time data.
        J Toxicol Clin Toxicol. 1991; 29: 11-21
        • Rosanky SJ
        Isopropyl alcohol poisoning treated with hemodialysis: Kinetics of isopropyl alcohol and acetone removal.
        J Toxicol Clin Toxicol. 1982; 19: 265-271
        • Bougneres PF
        • Lemmel C
        • Ferré P
        • et al.
        Ketone body transport in the human neonate and infant.
        J Clin Invest. 1986; 77: 42-48
        • Bougneres PF
        • Ferré P
        Study of ketone body kinetics in children by a combined perfusion of 13C and 2H3 tracers.
        Am J Physiol. 1987; 253: E496-E502
        • Lewin GA
        • Oppenheimer PR
        • Wingert WA
        Coma from alcohol sponging.
        J Am Coll Emerg Phys. 1977; 6: 165-167

      Article Info

      Publication History

      Accepted: April 27, 1992
      Received: March 3, 1992

      Identification

      DOI: https://doi.org/10.1016/0735-6757(92)90179-2

      Copyright

      © 1992 Published by Elsevier Inc.

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