Scurvy: historical review and current diagnostic approach

  • Laura Pimentel
    Correspondence
    Address reprint requests to Laura Pimentel, MD, Division of Emergency Medicine, University of Maryland School of Medicine, 419 West Redwood Street, Suite 280, Baltimore, MD 21201, USA
    Affiliations
    Division of Emergency Medicine, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
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      Abstract

      Scurvy, a deficiency of vitamin C, now most often occurs in disadvantaged groups seen frequently in EDs: alcoholics with poor nutrition, the isolated elderly, and the institutionalized. Its prominent clinical features are lethargy; purpuric lesions, especially affecting the legs; myalgia; and, in advancing disease, bleeding from the gums with little provocation. Common misdiagnoses are vasculitis, blood dyscrasias, and ulcerative gingivitis. Untreated, scurvy is inevitably fatal as a result of infection or sudden death. Fortunately, individuals with scurvy, even those with advanced disease, respond favorably to administration of vitamin C.

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      References

        • Kieffer P.
        • Thannberger P.
        • Wilhelm J.M.
        • Kieffer C.
        • Schneider F.
        Multiple organ dysfunction dramatically improving with the infusion of vitamin C.
        Intensive Care Med. 2001; 27: 448
        • Oeffinger K.C.
        Scurvy.
        Am Fam Phys. 1993; 48: 609-613
        • Magner L.N.
        A History of Medicine. Marcel Dekker, New York1992
        • Hockberger R.S.
        • Binder L.S.
        • Graber M.A.
        • et al.
        American College of Emergency Physicians Core Content Task Force II. The model of the clinical practice of emergency medicine.
        Ann Emerg Med. 2001; 37: 745-770
        • Stephen R.
        • Utecht T.
        Scurvy identified in the emergency department.
        J Emerg Med. 2001; 21: 235-237
        • Stewart C.P.
        • Cuthrie D.
        Lind’s Treatise on Scurvy. A bicentenary volume containing a reprint of the first edition of A Treatise of the Scurvy by James Lind. Edinburgh University Press, Edinburgh1953
        • Forbes G.B.
        Potatoes.
        Nutr Today. 1993; 28: 33
        • Hampl J.S.
        • Johnston C.S.
        • Mills R.A.
        Scourge of black-leg (scurvy) on the Mormon trail.
        Nutrition. 2001; 17: 416-418
        • Rajakumar K.
        Infantile scurvy.
        Pediatrics. 2001; 108: E76-E78
        • Holst A.
        Experimental studies relating to ship-beri-beri and scurvy. I. Introduction.
        J Hyg. 1907; 7 (Cambridge).: 619-633
        • Holst A.
        • Frolich T.
        Experimental studies relating to ship-beri-beri and scurvy. II. On the etiology of scurvy.
        J Hyg. 1907; 7 (Cambridge).: 634-671
        • Levine M.
        New concepts in the biology and biochemistry of ascorbic acid.
        N Engl J Med. 1986; 314: 892-902
        • Leung F.W.
        • Guze P.A.
        Adult scurvy.
        Ann Emerg Med. 1981; 10: 652-655
        • Hodges R.E.
        • Hood J.
        • Canham J.E.
        • Sauberlich H.E.
        • Baker E.M.
        Clinical manifestations of ascorbic acid deficiency in man.
        Am J Clin Nutr. 1971; 24: 432-443
        • Pangan A.L.
        • Robinson D.
        Hemarthrosis as initial presentation of scurvy.
        J Rheumatol. 2001; 28: 1923-1925
        • Sament S.
        Cardiac disorders in scurvy.
        N Engl J Med. 1970; 282: 282-283
        • Spodick D.H.
        Another cardiac disorder in scurvy.
        N Engl J Med. 1970; 282: 686
        • Estes J.W.
        Naval Surgeon. Watson Publishing International, Canton, MA1998
        • Russell R.M.
        Vitamin and trace mineral deficiency and excess.
        in: Braunwald E. Fauci A.S. Kasper D.L. Harrison’s Principles of Internal Medicine. 15th ed. McGraw-Hill, New York2001: 461-470
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