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Type B lactic acidosis, lactate accumulation without any clinical evidence of tissue hypoxia, occurs because of impairment in lactate use. Type B is further divided into subcategories based on underlying etiology. Type B1 is associated with systemic disease such as renal and hepatic failure, diabetes, and malignancy. Type B3 is associated with inherited metabolic disorders. Type B2 is known to be caused by several classes of drugs including biguanides, alcohols, iron, isoniazid, and salicylates.

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