Lactic acidosis caused by nucleoside analogues
Presented as a poster at the 2001 Research Day for the American College of Physicians, Maryland Chapter.
Department of Emergency Medicine, East Carolina University, Greenville, NC 27834, USA
Department of Internal Medicine, East Carolina University, Greenville, NC 27834, USA
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Type B lactic acidosis, lactate accumulation without any clinical evidence of tissue hypoxia, occurs because of impairment in lactate use. Type B is further divided into subcategories based on underlying etiology. Type B1 is associated with systemic disease such as renal and hepatic failure, diabetes, and malignancy. Type B3 is associated with inherited metabolic disorders. Type B2 is known to be caused by several classes of drugs including biguanides, alcohols, iron, isoniazid, and salicylates.
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© 2005 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
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