We really appreciate Dr Eken's inspiring feedback about our article entitled “Acid-base interpretation can be the predictor of outcome among patients with acute organophosphate poisoning before hospitalization.” In regard to the null hypothesis, H1, that acidosis is associated with mortality regardless of the underlying condition, we agreed with Dr Eken's opinion that acidosis is a life-threatening condition. However, quite a few studies have shown that acidosis may not be associated with mortality in certain groups of patients[1-4], suggesting the need to study the influence of acidosis in patients with difference underlying conditions.