Sunitinib-induced myxedema coma
Department of Emergency Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, 100, Taiwan
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Fig. 1
Desquamation of hand (A) and callouslike blisters at pressure areas of foot (B) due to sunitinib-induced hand-foot skin reaction.
Myxedema coma, the most extreme form of untreated hypothyroidism, is associated with a high mortality rate. A high index of clinical suspicion and recognition of potential precipitating factors for myxedema coma are crucial for emergency department physicians so that they can make a timely diagnosis and initiate appropriate treatment. We report the first documented case of sunitinib-induced myxedema coma in a patient who was presented to the emergency department with severe hypothermia. Physicians should be aware of this potential complication among patients treated with sunitinib for cancer.
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© 2009 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
