Trastuzumab (Herceptin)–associated cardiomyopathy presented as new onset of complete left bundle-branch block mimicking acute coronary syndrome: a case report and literature review
Chung-Ming Tu, MD
Division of Cardiology Department of Medicine, Song-Shan Armed Forces General Hospital, Taipei, Taiwan, R.O.C.
Division of Cardiology Department of Medicine, Tri-Service General Medical Center, Taipei, Taiwan, R.O.C.
Kai-Ming Chu, MD, PhD
Division of Cardiology Department of Medicine, Tri-Service General Medical Center, Taipei, Taiwan, R.O.C.
Shin-Ping Yang, MD, PhD
Division of Cardiology Department of Medicine, Tri-Service General Medical Center, Taipei, Taiwan, R.O.C.
Shu-Mung Cheng, MD, PhD
Division of Cardiology Department of Medicine, Tri-Service General Medical Center, Taipei, Taiwan, R.O.C.
Division of Cardiology Department of Medicine, Song-Shan Armed Forces General Hospital, Taipei, Taiwan, R.O.C.
Division of Cardiology Department of Medicine, Tri-Service General Medical Center, Taipei, Taiwan, R.O.C.
References
- [1]Slamon, DJ, Leyland-Jones, B, Shak, S et al, Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 2001;344:783–792.
- [2]Romond, EH, Perez, EA, Bryant, J et al, Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med. 2005;353:1673–1684.
- [3]Piccart-Gebhart, MJ, Procter, M, Leyland-Jones, B et al, Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med. 2005;353:1659–1672.
- [4]Joensuu, H, Kellokumpu-Lehtinen, PL, Bono, P et al, Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. N Engl J Med. 2006;354:809–820.
- [5]Slamon, D, Eiermann, W, Robert, N et al, Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab with docetaxel, carboplatin and trastuzumab in HER-2 positive early breast cancer patients: BCIRG 006 study. Breast Cancer Res Treat. 2005;94:S5 ([abstr 1]).
- [6]Yeon, CH, Pegram, MD. Anti-erbB-2 antibody trastuzumab in the treatment of HER2-amplified breast cancer. Invest New Drugs. 2005;23:391–409.
- [7]Suter, TM, Cook-Bruns, N, Barton, C. Cardiotoxicity associated with trastuzumab (Herceptin) therapy in the treatment of metastatic breast cancer. Breast. 2004;13:173–183.
- Abstract
- | Full Text
- | Full Text PDF
- | PubMed
- | Scopus (121)
- [8]Wong, SF. Trastuzumab and cardiotoxicity: weighing the risks. Am J Health Syst Pharm. 2006;63:525.
- CrossRef
- | PubMed
- | Scopus (2)
- [9]Schneider, JW, Chang, AY, Garratt, A. Trastuzumab cardiotoxicity: speculations regarding pathophysiology and targets for further study. Semin Oncol. 2002;29:22–28.
- Abstract
- | Full Text
- | Full Text PDF
- | PubMed
- [10]Ewer, MS, Vooletich, MT, Durand, J-B, Woods, ML, Davis, JR, Valero, V et al, Reversibility of trastuzumab-related cardiotoxicity: new insights based on clinical course and response to medical treatment. J Clin Oncol. 2005;23:7820–7826.
- [11]Sliwkowski, MX, Lofgren, JA, Lewis, GD et al, Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin). Semin Oncol. 1999;26:60–70.
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