Leone at al [1] have found a surge of serum level of endogenous granulocyte colony-stimulating factor (G-CSF) is in proportion to the circulation of CD34⁺ progenitor cells after acute myocardial infarction. This observation supported the notion that the myocardial regeneration commenced as early as the beginning of cardiomyocyte death in the form of motivating CD34⁺ progenitor cells from bone marrow in response to a variety of cytokines and G-CSF [2]. With clinical experience of the use of G-CSF administration, the side effect of severe bone pain is frequently encountered accounting for 1% to 5% of all cases.