Advertisement
Advanced Search

To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect.

Figures

Fig. 1

Multivariate analysis of death and dependence 6 months after TIA. (Reprinted with permission from Daffertshofer M, Mielke O, Pullwitt A, Felsenstein M, Hennerici M. Transient ischemic attacks are more than “ministrokes.” Stroke. 2004; 35:2453-8.)

Fig. 2

Time to first event included in composite end point (nonfatal stroke, TIA, nonfatal myocardial infarction, and major bleeding complications) in patients with ischemic stroke treated with aspirin 25 mg plus dipyridamole 200 mg twice daily (early initiation group) or aspirin 100 mg (late initiation group) within 24 h of symptom onset for the first 7 days followed by aspirin 25 mg plus dipyridamole 200 mg twice daily for up to 90 days. (Hazard ratio [HR, 0.73, 95% confidence interval [CI] 0.44 to 1.19; P = .20). (Republished with permission from Dengler R, Diener HC, Schwartz A, Grond M, Schumacher H, Machnig T, Eschenfelder CC, Leonard J, Weissenborn K, Kastrup A, Haberl R; EARLY Investigators. Early treatment with aspirin plus extended-release dipyridamole for transient ischaemic attack or ischaemic stroke within 24 h of symptom onset (EARLY trial): a randomised, open-label, blinded-endpoint trial. Lancet Neurol. 2010;9(2):159-66.)

Abstract

Many patients with transient ischemic attacks (TIA) are at high risk of stroke within the first few days of onset of symptoms. Emergency physicians and primary care physicians need to assess these patients quickly and initiate appropriate secondary stroke prevention strategies. Recent refinements in diagnostic imaging have produced valuable insight into risk stratification of patients with TIA. Clinical data regarding urgent initiation of antiplatelet therapy specifically in this patient population with non-cardioembolic TIA are limited but promising. This review outlines the diagnostic tools available for rapid assessment of patients presenting with symptoms of TIA and discusses clinical trials that apply to these vulnerable patients.

To access this article, please choose from the options below

Log In


Forgot password?

Register

Create a new account

Purchase access to this article

Claim Access

If you are a current subscriber with Society Membership or an Account Number, claim your access now.

Subscribe to this title

Purchase a subscription to gain access to this and all other articles in this journal.

Institutional Access

Visit ScienceDirect to see if you have access via your institution.

Disclosure: This work was supported by Boehringer Ingelheim Pharmaceuticals, Inc (BIPI). Writing and editorial assistance was provided by Ann Sherwood, PhD, of Publication CONNEXION (Newtown, PA), which was contracted by BIPI for these services. The author meets criteria for authorship as recommended by the International Committee of Medical Journal Editors (ICMJE), was fully responsible for all content and editorial decisions, and was involved at all stages of manuscript development. The author received no compensation related to the development of the manuscript.

☆☆Author Funding: 1. NIH/NINDS Research Grant Support, 2. Genentech Speaker's Bureau.

Related Articles

Searching for related articles..

Advertisement