Practical considerations in emergency management of bleeding in the setting of target-specific oral anticoagulants

Michael P. Miller; Toby C. Trujillo; Kristen E. Nordenholz

doi:10.1016/j.ajem.2013.11.044

Switch to Standard View Switch to Enhanced View

Practical considerations in emergency management of bleeding in the setting of target-specific oral anticoagulants☆☆☆

Michael P. Miller, MD

Toby C. Trujillo, PharmD

Kristen E. Nordenholz, MD, MSc

DOI: http://dx.doi.org/10.1016/j.ajem.2013.11.044

Article Info

Purchase this article (PDF Included)

$31.50 USD (24 hour access)

Subscribe to this title

To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect.

Abstract

The recent arrival of the target-specific oral anticoagulants (TSOACs) offers potential advantages in the field of anticoagulation. However, there are no rapid and accurate and routinely available laboratory assays to evaluate their contribution to clinical bleeding. With the expanding clinical indications for the TSOACs, and the arrival of newer reversal agents on the market, the emergency clinician will need to be familiar with drug specifics as well as methods for anticoagulation reversal. This review offers a summary of the literature and some practical strategies for the approach to the patient taking TSOACs and the management of bleeding in these cases.

To access this article, please choose from the options below

Log In

Register

Create a new account

Purchase access to this article

$31.50 USD|Online access for 24 hours

Claim Access

If you are a current subscriber with Society Membership or an Account Number, claim your access now.

Subscribe to this title

Purchase a subscription to gain access to this and all other articles in this journal.

Institutional Access

Visit ScienceDirect to see if you have access via your institution.

☆Disclosures: Kristen Nordenholz has participated in unrestricted research with Alere, Inc; Genentech, Inc; and Boehringer-Ingelheim. Toby Trujillo consults for Boehringer-Ingelheim, Bristol-Meyers Squibb, and Janssen Pharmaceuticals.

☆☆Classifications: Hematology, Pharmacology, Pulmonary Embolism, Resuscitation.

Practical considerations in emergency management of bleeding in the setting of target-specific oral anticoagulants☆☆☆

Affiliations

Affiliations

Affiliations

Correspondence

Affiliations

Correspondence

Article Info

Abstract

To access this article, please choose from the options below

Log In

Register

Purchase access to this article

Claim Access

Subscribe to this title

Institutional Access

Article Tools

Related Articles