Vitamin K2 for the reversal of warfarin-related coagulopathy

Toru Hifumi; Hiroaki Takada; Daisuke Ogawa; Kenta Suzuki; Hideyuki Hamaya; Natsuyo Shinohara; Yuko Abe; Koshiro Takano; Kenya Kawakita; Masanobu Hagiike; Yuichi Koido; Yasuhiro Kuroda

doi:10.1016/j.ajem.2015.01.002

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Vitamin K2 for the reversal of warfarin-related coagulopathy

Toru Hifumi, MD

Kagawa University Hospital, Emergency Medical Center, Kita, Kagawa, 761-0793, Japan

Hiroaki Takada, MD

Department of Critical Care Medicine and Trauma National Hospital Organization Disaster Medical Center, Tokyo, 190-0014, Japan

Daisuke Ogawa, MD

Kenta Suzuki, MD

Hideyuki Hamaya, MD

Natsuyo Shinohara, MD

Yuko Abe, MD

Koshiro Takano, MD

Kenya Kawakita, MD

Masanobu Hagiike, MD

Kagawa University Hospital, Emergency Medical Center, Kita, Kagawa, 761-0793, Japan

Yuichi Koido, MD

Department of Critical Care Medicine and Trauma National Hospital Organization Disaster Medical Center, Tokyo, 190-0014, Japan

Yasuhiro Kuroda, MD

Kagawa University Hospital, Emergency Medical Center, Kita, Kagawa, 761-0793, Japan

DOI: http://dx.doi.org/10.1016/j.ajem.2015.01.002

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The American Heart Association/American College of Cardiology Foundation recommends vitamin K1 for warfarin-related coagulopathy. In Japan, vitamin K2 is used more commonly for such purpose. The difference between vitamins K1 and K2 in reversing warfarin-related coagulopathy has not been discussed. Herein, we report a case that was reversed with vitamin K2; alterations in vitamins K1 and K2 levels and coagulation markers are also presented.

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Vitamin K2 for the reversal of warfarin-related coagulopathy

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