Abstract
Background
There have been sporadic case reports published focusing on myoglobin and sepsis.
However, there are no systematic studies evaluating the correlation between myoglobin
level and sepsis. This study investigated the correlation between the serum myoglobin
level and the severity of septic patients. Next, we assessed the predictive value
of the serum myoglobin level for the prognosis of septic patients.
Methods
Seventy septic patients were included and subdivided into the following 3 groups:
sepsis group, severe sepsis group, and septic shock group. We collected blood samples
at 0, 6, 12, 18, and 24 hours after admission. The serum levels of myoglobin, C-reactive protein, and procalcitonin
were analyzed. We also evaluated the levels of malondialdehyde, which is a biomarker
for oxidative stress.
Results
The data indicate that the myoglobin level increased gradually within 24 hours after admission. The median myoglobin levels of the sepsis, severe sepsis, and
septic shock groups were 635.7, 903.6, and 1094.8 μg/L, respectively (P < .05). The elevated myoglobin level was positively correlated with Sequential Organ
Failure Assessment score, C-reactive protein, and procalcitonin level in septic patients.
The increased myoglobin level was also associated with the mortality of septic patients.
The Kaplan-Meier survival curves indicated that patients with high myoglobin levels
had an elevated mortality rate. Moreover, an elevated myoglobin level indicated more
oxidative stress.
Conclusions
The myoglobin level can be detected in the early stage of sepsis and may serve as
a potential biomarker for evaluating sepsis severity and further prognosis.
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Article Info
Publication History
Published online: January 08, 2016
Accepted:
January 7,
2016
Received in revised form:
January 6,
2016
Received:
June 14,
2015
Footnotes
☆This study was supported by grants from the National High Technology Research and Development Program of China (863 Program) (no. 2011AA02A111 ).
☆☆Declaration of interest: We declare that we have no conflict of interest.
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
