We have greatly enjoyed reading the recently published article by Yao et al [1] entitled “Higher serum level of myoglobin could predict more severity and poor outcome for patients with sepsis.” We thank them for sharing their experience; however, we have some concerns about the article. Patients with severe sepsis or septic shock have a high mortality [2] . The pathophysiology of sepsis may link to multiple mechanisms and is commonly associated with myocardial dysfunction [3] . Therefore, a prognostic evaluation is of importance for the outcome of patients with severe sepsis or septic shock.