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We read with great interest the recent case report entitled “Streptococcus pneumoniae meningitis without pleocytosis of the cerebrospinal fluid” by Sato et al [1]. The patient had a small spleen (6 × 2 × 1 cm) requiring prompt treatment, as duly administered by the authors. We would like here to propose that the patient with small spleen should be considered as a potentially immunocompromised patient.

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