We are pleased that our paper raised an interest among readers of the American Journal of Emergency Medicine [1] On behalf of co-authors, I would like to reply to the letter of titled by “Reversible Brugada-like electrocardiogram and acute renal failure, in a patient with takotsubo syndrome”. The brain, autonomic nerves, and heart are considered as an interactive system. “My heart is burning” is a common metaphor used to describe the intense emotional pain. Indeed, often emotional pain, sadness, or grief are experienced as physical pain distinctly in the heart region [2].