Abstract
Objective
This study aimed to compare 2 fluid infusion rates of lactated Ringer (LR) and hydroxyethyl
starch (HES) 130/0.4 on hemodynamic restoration at the early phase of controlled hemorrhagic
shock.
Methods
Fifty-six anesthetized and ventilated piglets were bled until mean arterial pressure
(MAP) reached 40 mm Hg. Controlled hemorrhage was maintained for 30 minutes. After
this period, 4 resuscitation groups were studied (n = 14 for each group): HES infused at 1 or 4 mL/kg per minute or LR1 infused at 1 or 4 mL/kg per minute until baseline MAP was restored. Hemodynamic assessment using PiCCO
monitoring and biological data were collected.
Results
Time to restore baseline MAP ±10% was significantly lower in LR4 group (11 ± 11 minutes) compared to LR1 group (41 ± 25 minutes) (P = .0004). Time to restore baseline MAP ±10% was significantly lower in HES4 group (4 ± 3 minutes) compared to HES1 (11 ± 4 minutes) (P = .0003). Time to restore baseline MAP ±10% was significantly lower with HES vs LR whatever the infusion rate.
No statistically significant difference was observed in cardiac output, central venous
saturation, extravascular lung water, and arterial lactate between 4 and 1 mL/kg per
minute groups.
Conclusions
In this controlled hemorrhagic shock model, a faster infusion rate (4 vs 1 mL/kg per minute) significantly decreased the time for restoring baseline MAP, regardless
of the type of infused fluid. The time for MAP restoration was significantly shorter
for HES as compared to LR whatever the fluid infusion rate.
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Article Info
Publication History
Published online: May 13, 2016
Accepted:
May 10,
2016
Received:
April 9,
2016
Footnotes
☆Funding: This study was funded by public grants obtained from Physiology Department, EA 2992, Faculté de Médecine de Nîmes, Université Montpellier 1, Boulevard Kennedy 30,029 Nîmes, France.
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
