Abstract
Background
Previous studies have confirmed that low serum albumin levels in acute ischemic stroke
patients increased the risk for poor outcome and death, demonstrating the neuroprotective
role of albumin. However, there are few studies investigating the relationship between
albumin levels and recurrence of stroke. The aim of this study was to evaluate the
effect of serum albumin level on the risk of recurrence in patients with acute ischemic
stroke.
Methods
Seven hundred fifty-three consecutive patients with acute first-ever ischemic stroke
were recruited in this study. Recurrent outcome was measured 1 year after stroke through
home interviews (n = 692).
Results
Patients with recurrence had significantly lower serum albumin level than those without
recurrence (37.07 ± 4.21 vs 38.91 ± 3.25). The multiple logistic regression adjustment
for confounding factors showed that the association remained significant for patients
in the second albumin quartile, the third quartile, and the fourth quartile compared
with patients in the first quartile (adjusted odds ratio [aOR] = 0.543, 95% confidence
interval [CI]: 0.307-0.959, P= .036; aOR = 0.449, 95% CI: 0.249-0.812, P= .008; and aOR = 0.290, 95% CI: 0.148-0.570, P < .001).
Conclusion
Lower serum albumin level increases the risk of recurrence in patients with acute
ischemic stroke, suggesting that serum albumin level might be used as an indicator
for stroke recurrence.
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Article Info
Publication History
Published online: June 13, 2016
Accepted:
June 9,
2016
Received:
June 9,
2016
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
