Abstract
This study aimed to compare the analgesic effects of intravenous ibuprofen and intravenous
morphine titration for femoral shaft fractures in adult patients. In total, 293 participants
were enrolled and randomly received intravenous ibuprofen or intravenous morphine
titration. Their visual analogue scale (VAS) results were recorded every 5 minutes
after the first administration. The VAS scores before and during transport were also
measured. Meanwhile, the type and frequency of the adverse effects were also recorded
in both groups. Patients treated with morphine showed a faster and greater reduction
in the VAS than those in the ibuprofen group within 1 hour after the first administration.
Interestingly, intravenous morphine titration provided consistent analgesia even during
the further transport. No significant immediate adverse event was observed in all
of the participants, except for sedation, which might be beneficial for keeping the
patient quiet and might not be arbitrarily attributed to adverse effects. No addiction
was noted in the morphine group. This study demonstrated that intravenous morphine
titration is a faster and more efficient analgesia for femoral shaft fractures than
ibuprofen in adult patients immediately after injury.
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Article Info
Publication History
Published online: July 19, 2016
Accepted:
July 16,
2016
Received in revised form:
July 15,
2016
Received:
May 13,
2016
Footnotes
â?†Acknowledgments: This work was supported by grants from the National Natural Science Foundation of China (no. 81371940 ).
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
