Abstract
Background
Given the increasing number of patients with acute renal colic, the present study
examined the analgesic effects of haloperidol with or without morphine in order to
find an effective method with fewer side effects for pain reduction in these patients.
Method
In the present randomized double-blind clinical trial study, patients with a pain
severity score of above 3 were randomly divided into 2 equal groups: Group A received
intravenous morphine and haloperidol, and Group B received intravenous morphine with
normal saline. Pain severity was recorded at Times 0, 20, 40, and 60 min following
the injections based on a visual pain analog scale (VPAS) from 0 to 10.
Results
A total of 140 patients were included in this study. A comparison of the recorded
pain severity scores did not show a significant difference between the 2 study groups
(P = 0.38). The mean heart rate, the mean systolic and diastolic blood pressures, and
the mean incidence rate of nausea and vomiting were not significantly different between
Group A and Group B. The frequency of extrapyramidal side effects was 4.3% in the
haloperidol group, which was not significantly different from that of the other group.
The frequency of extra analgesic requirement was not significantly different between
the 2 groups (P = 0.05).
Conclusion
In our patients with acute renal colic, haloperidol failed to reduce pain and the
incidence of nausea or vomiting, while it caused extrapyramidal side effects. Therefore,
the prescription of this medication for acute pains, especially in renal colic, is
not recommended.
Keywords
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Article Info
Publication History
Published online: October 18, 2018
Accepted:
October 17,
2018
Received in revised form:
October 16,
2018
Received:
September 6,
2018
Identification
Copyright
© 2018 Elsevier Inc. All rights reserved.
