Which one is more important in traumatic brain injury: Hypotension or hypoxia?

I have greatly enjoyed reading the recently published article by Seo et al. [ ]. In this study, the authors examined the association between hypoxia level and outcomes according to shock status in traumatic brain injury (TBI) patients. They found that the mortality rates were 49.4% in severe hypoxia, 30.7% in mild hypoxia, 18.5% in normoxia. Mortality rates were 47.1% in TBI patients with shock status and 20.5% in non-shock TBI patients. There was a trend toward worsened outcomes with mild and severe hypoxia in patient with and without shock, however, the only met statistical significance for patients with both severe hypoxia and non-shock status. These results suggested that, in patients already suffering hypotension, hypoxia did not add any significant effect.