a b s t r a c t

Introduction: Since the beginning of the novel coronavirus (COVID-19) pandemic in the United States, there have been concerns about the potential impact of the pandemic on persons with Opioid use disorder. Shelter-in-place (SIP) orders, which aimed to reduce the spread and scope of the virus, likely also impacted this patient popula- tion. This study aims to assess the role of the COVID-19 pandemic on the incidence of opioid overdose before and after a SIP order.

Methods: A retrospective review of the incidence of opioid overdoses in an urban three-hospital system was con- ducted. Comparisons were made between the first 100 days of a city-wide SIP order during the COVID-19 pan- demic and the 100 days during the COVID-19 pandemic preceding the SIP order (Pre-SIP). Differences in observed incidence and expected incidence during the SIP period were evaluated using a Fisher’s Exact test.

Results: Total patient visits decreased 22% from 46,078 during the Pre-SIP period to 35,971 during the SIP period. A total of 1551 opioid overdoses were evaluated during the SIP period, compared to 1665 opioid overdoses dur- ing the Pre-SIP period, consistent with a 6.8% decline. A Fisher’s Exact Test demonstrated a p < 0.0001, with a cor- responding Odds Ratio of 1.20 with a 95% confidence interval (1.12;1.29).

Conclusion: The COVID-19 pandemic and the associated SIP order were associated with a statistically and clini- cally significant increase in the proportion of opioid overdoses in relation to the overall change in total ED visits.

(C) 2020

1. Introduction

Prior to the novel coronavirus (COVID-19) pandemic, Healthcare practitioners in the US were battling with a different epidemic- the opioid crisis. Similar to COVID-19, the weight of opioid overdose care is managed by emergency departments (EDs) across the country. Prior to the COVID-19 pandemic, ED patient volumes were steadily in- creasing [1,2]. Since the start of the COVID-19 pandemic, normally over- crowded EDs have been less congested. Media outlets and studies have reported that in many EDs, visits have nearly dropped in half [3-5]. This striking disappearance of everyday emergencies has been noted both nationally and internationally, but less is known about the effect of the COVID-19 pandemic on opioid overdose rates [6-11].

Data published by the Center for Disease Control and Prevention showed that in 2017 the opioid crisis took the lives of 130 Americans

* Corresponding author.

E-mail addresses: [email protected] (J. Rosenbaum), [email protected] (N. Lucas), [email protected] (G. Zandrow), [email protected] (W.A. Satz),

[email protected] (D. Isenberg), [email protected] (J. D’Orazio),

[email protected] (N.T. Gentile), [email protected] (K.E. Schreyer).

per day. Drug overdoses have dramatically increased over the past two decades [12,13]. As increasing numbers of patients are being treated for opioid overdose, many organizations have expressed con- cern that the COVID-19 pandemic may disproportionately affect per- sons with Substance use disorders (SUDs) [14,15]. social support is crucial for those being treated for SUDs, and stress and isolation put per- sons at risk for relapse [16]. Persons with SUD face unique challenges during times of quarantine and Stay at Home orders. Many individuals with SUDs have underlying health conditions, particularly cardio- vascular and pulmonary diseases and Hepatitis C or Human Immuno- deficiency Virus-1 infection [16]. Coupled with a lack of resources for social distancing and hygiene, these populations are more vulnera- ble to COVID-19 transmission [17]. Previous studies have also demonstrated that Economic conditions may be a strong predictor of drug-related deaths [18]. Additionally, people with SUDs are also at a particularly heightened risk of suicide [19]. While efforts to physically distance are vital to slow the spread of the virus, this may have unin- tended consequences on mental health and persons with SUDs are likely to suffer more greatly from the psychosocial burden [20].

Furthermore, persons seeking treatment for Opioid use disorder may require frequent medical appointments, individual or group therapy, or daily visits to methadone clinics. Disruption of care

https://doi.org/10.1016/j.ajem.2020.12.047

0735-6757/(C) 2020

is a large threat to addiction treatment, and the COVID-19 pandemic en- tered the US just as more and more people were gaining access to SUD treatment and medication assisted therapy [21]. This prompted some practitioners in the US to advocate for expanded mobile and telemedi- cine solutions for SUDs during the pandemic [22]. In fact, the Drug En- forcement Administration demonstrated quick legislative change and permitted prescription of buprenorphine through telemedicine [23]. During the pandemic in China, authorities required public security de- partments to ensure that methadone was delivered from clinics to their patients’ homes [24].

At the beginning of the pandemic, many large cities enacted “shel- ter-in-place” (SIP) orders, in an attempt to limit the spread of COVID- 19 [25]. Philadelphia, Pennsylvania enacted a similar order, which went into effect on March 23rd, 2020 and ended June 4th, 2020. Under the order’s provisions all public and private gatherings of any number of people occurring outside a single household were prohibited with exceptions made for essential businesses or essential personal ac- tivities [26]. These measures are important for limiting spread of disease in a pandemic, but may further personal isolation.

Reports from national, state and local media outlets have suggested increases in opioid-related mortality during the COVID-19 pandemic [27-30]. Despite these concerns, there has been little published data re- garding the impact of the COVID-19 pandemic on reported opioid over- doses. This study aimed to assess the role of the COVID-19 pandemic and the associated SIP order on the incidence of opioid overdoses.

1. Methods

This was a retrospective, observational study of patients seen in our health system in Philadelphia, PA. Total annual volume in the health system in 2019 was approximately 180,000 visits. Charts of those pa- tients evaluated for opioid overdose were identified using the EPIC elec- tronic health record system (Verona, WI) via ICD10 codes T40.0-40.4, T40.6, F11.0-F11.9. These codes include diagnoses such as poisoning by heroin, poisoning by other opioids, and poisoning by narcotics, which represent various classifications of opioid overdose.

The study period included 100 days after a shelter-in-place (SIP)

order in Philadelphia, from March 23, 2020 – June 30, 2020. This was compared to the 100 days prior to the SIP order (Pre-SIP), from Decem- ber 14, 2019 – March 22, 2020. To account for changes in overall ED vol- ume, a Central Fisher’s Exact Test was used to compare the ratio of observed to expected patients evaluated during both time periods. This study was not considered human subject research by our Institu- tional Review Board.

1. Results

Summary data is shown in Table 1. Overall patient visits decreased 22%, from 46,078 during the Pre-SIP period to 35,971 during the SIP period. There was a 6.8% decline in overdoses, from 1665 during the Pre-SIP period, to 1551 during the SIP period. The difference between expected and observed opioid overdoses in the study EDs was signifi- cant (p < 0.0001), with a corresponding Odds Ratio of 1.202 and a 95% Confidence interval of 1.12 to 1.29 (Fig. 1).

Fig. 1. Comparison of daily opioid overdoses. This figure illustrates the distribution of daily number of overdose patients evaluated per study period.

1. Discussion

This study evaluated the impact of the COVID-19 pandemic and a concomitant SIP order on the incidence of opioid overdoses. We found a 22% decrease in the total number of patients seen in the ED during the SIP period. There was a significantly smaller decrease of 6.8% in opi- oid overdoses during the same time period. Therefore, although the ab- solute number of opioid overdoses declined during the SIP period, there were proportionally more opioid overdoses during that period, com- pared to overall ED volume. This suggests that opioid overdoses contin- ued at a large rate despite the SIP order.

In the city of Philadelphia, opioid overdoses have been increasing steadily since at least 2013 [31]. Based on prior trajectories, the rate of overdose was expected to continue to increase in 2020. Overall over- dose deaths in Philadelphia are about the same this year as they were last year, though notability both fatal and nonfatal opioid overdoses in- creased in black residents [32].

It seems likely that the COVID-19 pandemic slowed the rate of in- crease in opioid overdose presentations to EDs, rather than caused a true decrease in overdoses. By comparison, one ED in Virginia noted that their total number of nonfatal opioid overdose visits doubled in the first four months of the COVID-19 pandemic compared to the year prior [33]. Similarly, data from the Kentucky State Ambulance Reporting System demonstrated a 17% increase in EMS opioid overdose runs and a 50% increase in runs for suspected opioid overdose with deaths at the scene after a state of emergency was declared [34]. This study also dem- onstrated a 71% increase in EMS runs with refused transportation to an ED suggesting that patients are less likely to present to a hospital. Mul- tiple previous studies have noted a decrease in presentation of everyday emergencies, speculating that patients, including those with opioid use disorder, may be fearful to present to an ED during a pandemic [8-11]. The cause of the decrease in opioid overdose presentation is likely multifactorial. One possible explanation is that people that travel to the area near the study site to obtain opioids did not do so out of fear of exposure, and instead obtained opioids in their local areas. By- standers may have been less likely to contact 9-1-1 in an effort to avoid EDs during the pandemic. It is also possible that the broad avail- ability and use of Naloxone, by both First responders and bystanders,

Table 1

Incidence of opioid overdoses.

SIP = Shelter In Place (3/23/20-06/30/20); Pre-SIP = pre-Shelter in Place (12/14/19-03/22/2020); Incidence reported as daily mean +/- 2 standard deviations.

may have limited the number of opioid overdose presentations. Fur- thermore, the US enacted travel bans from China on February 2nd, 2020, and parts of Europe on March 11th, 2020. It is likely that travel re- strictions and social distancing also impacted imports from Mexico to the US. Wuhan, China was well-known as a hub for Fentanyl, whereas Mexico is known for Fentanyl, Heroin, Cocaine, and Methamphetamines [35,36]. The US DEA has reported disruptions in supply-chains of illegal drugs all over the US, including in Philadelphia [36]. With reduction in supply comes increased demand, which is almost always followed by increased prices. The combination of a reduced supply and higher cost may have impacted those with OUD and limited their ability to pur- chase and use opioids.

The significant impact of the SIP order is curious, because many pa- tients seen in the study ED for overdose are un-domiciled, and therefore, have nowhere to shelter. During the SIP order, private transportation modalities, such as Uber and Lyft, were not as available, and public transportation schedules were altered to reduce trips and hours. The impact of the SIP on transportation modalities could have further im- pacted the population that travels to the study area to obtain opioids, rather than the population that resides in the study area.

1. Limitations

This study was conducted within a single health system in an urban setting that cares for a high number of patients presenting with opioid use disorder, and so, results may not be generalizable to all hospital set- tings or patient populations. While this study examined the 100 days after the SIP order (March 23rd through June 30th, 2020), this order ex- pired on June 4th, 2020. We believe that the SIP order influenced culture which continued after the order; however, it is possible that people’s behavior changed immediately upon expiration of the order. Addition- ally, the ICD-10 codes used to capture visits related to opioid overdose were based on those used in existing literature, but may not have been inclusive of all visits related to opioid overdose. We were also un- able to capture data from opioid overdoses in the prehospital setting that did not present to the ED. Furthermore, our study did not measure mortality from overdoses during this timeframe.

1. Conclusion

The COVID-19 pandemic and the associated SIP order were associ- ated with an overall decrease in opioid overdoses. Compared to overall ED volume, however, the proportional increase in opioid overdoses was statistically and clinically significant.

Declaration of Competing Interest

None.

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