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Fig. 1
A, Head computed tomographic scan of patient OF on admission. An illustrative patient, OF is a 70-year-old woman with no history of coronary artery disease who presented with confusion. Her head computed tomographic scan showed right temporoparietal ICH. Her ECG showed T wave inversions in leads I, aVL, and V1 to V6. Her peak troponin was 1.8 ng/mL. The patient subsequently underwent a stress test performed with technetium Tc 99m sestamibi that disclosed a modest degree of reversible inferoapical defect. B, Electrocardiogram of patient OF on admission.
Abstract
Objectives
Myocardial injury is common among patients with intracerebral hemorrhage (ICH). However, it is challenging for emergency physicians to recognize acute myocardial injury in this population, as electrocardiographic (ECG) abnormalities are common in this setting. Our objective is to examine whether ischemic-appearing ECG changes predict subsequent myocardial injury in the context of ICH.
Methods
Consecutive patients with primary ICH presenting to a single academic center were prospectively enrolled. Electrocardiograms were retrospectively reviewed by 3 independent readers. Anatomical areas of ischemia were defined as I and aVL; II, III, and aVF; V1 to V4; and V5 and V6. Medical record review identified myocardial injury, defined as troponin I or T elevation (cutoff 1.5 and 0.1 ng/mL, respectively), within 30 days.
Results
Between 1998 and 2004, 218 patients presented directly to our emergency department and did not have a do-not-resuscitate/do-not-intubate order; arrival ECGs and troponin levels were available for 206 patients. Ischemic-appearing changes were noted in 41% of patients, and myocardial injury was noted in 12% of patients. Ischemic-appearing changes were more common in patients with subsequent injury (64% vs 37%; P = .02). After multivariable analysis controlling for age and cardiac risk factors, ischemic-appearing ECG changes independently predicted myocardial injury (odds ratio, 3.2; 95% confidence interval, 1.3-8.2). In an exploratory analysis, ischemic-appearing ECG changes in leads I and aVL as well as V5 and V6 were more specific for myocardial injury (P = .002 and P = .03, respectively).
Conclusion
In conclusion, although a range of ECG abnormalities can occur after ICH, the finding of ischemic-appearing changes in an anatomical distribution can help predict which patients are having true myocardial injury.
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☆Presentation information: Abstract presented at SAEM Annual Meeting, Chicago, IL, May 2007.
☆☆Conflicts of Interest Disclosure: Dr Joshua N. Goldstein has received consulting fees from CSL Behring.
★This study is funded by the National Institute of Neurological Disorders and Stroke ( NIH K23NS059774 ).
