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May 2012Volume 30, Issue 4, Pages 545–552
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Ischemic-appearing electrocardiographic changes predict myocardial injury in patients with intracerebral hemorrhage☆☆☆★

Kohei Hasegawa
x
Kohei Hasegawa
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Affiliations

  • Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
, MD
,
Megan L. Fix
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Megan L. Fix
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Affiliations

  • Department of Emergency Medicine, the University of Utah Hospital, Salt Lake City, UT, USA
, MD
,
Lauren Wendell
x
Lauren Wendell
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Affiliations

  • Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
, BS
,
Kristin Schwab
x
Kristin Schwab
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Affiliations

  • Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
, BS
,
Hakan Ay
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Hakan Ay
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Affiliations

  • Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
, MD
,
Eric E. Smith
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Eric E. Smith
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Affiliations

  • The Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
, MD, MPH
,
Steven M. Greenberg
x
Steven M. Greenberg
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Affiliations

  • Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
, MD, PhD
,
Jonathan Rosand
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Jonathan Rosand
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Affiliations

  • Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
  • The Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
, MD, MS
,
Joshua N. Goldstein
x
Joshua N. Goldstein
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Affiliations

  • Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
, MD, PhD
,
David F.M. Brown
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David F.M. Brown
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Affiliations

  • Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA 02114, USA

Correspondence

  • Corresponding author. Tel.: +1 617 7265273; fax: +1 617 7260311.
, MDcorrespondence
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David F.M. Brown
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Affiliations

  • Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA 02114, USA

Correspondence

  • Corresponding author. Tel.: +1 617 7265273; fax: +1 617 7260311.
DOI: http://dx.doi.org/10.1016/j.ajem.2011.02.007

References

  1. [1]Dixon, A.A., Holness, R.O., Howes, W.J. et al, Spontaneous intracerebral haemorrhage: an analysis of factors affecting prognosis. Can J Neurol Sci. 1985;12:267–271.
  2. [2]Qureshi, A.I., Tuhrim, S., Broderick, J.P. et al, Spontaneous intracerebral hemorrhage. N Engl J Med. 2001;344:1450–1460.
  3. [3]Tuhrim, S., Dambrosia, J.M., Price, T.R. et al, Prediction of intracerebral hemorrhage survival. Ann Neurol. 1988;24:258–263.
  4. [4]Broderick, J., Connolly, S., Feldmann, E. et al, Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: a guideline from the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working Group. Stroke. 2007;38:2001–2023.
  5. [5]Ronning, O.M., Guldvog, B., Stavem, K. The benefit of an acute stroke unit in patients with intracranial haemorrhage: a controlled trial. J Neurol Neurosurg Psychiatry. 2001;70:631–634.
  6. [6]Hemphill, J.C. III, Newman, J., Zhao, S. et al, Hospital usage of early do-not-resuscitate orders and outcome after intracerebral hemorrhage. Stroke. 2004;35:1130–1134.
  7. [7]Anderson, C.S., Huang, Y., Wang, J.G. et al, Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial. Lancet Neurol. 2008;7:391–399.
  8. [8]Diringer, M.N., Skolnick, B.E., Mayer, S.A. et al, Thromboembolic events with recombinant activated factor VII in spontaneous intracerebral hemorrhage: results from the Factor Seven for Acute Hemorrhagic Stroke (FAST) trial. Stroke. 2010;41:48–53.
  9. [9]Mayer, S.A., Brun, N.C., Begtrup, K. et al, Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med. 2005;352:777–785.
  10. [10]Diringer, M.N., Skolnick, B.E., Mayer, S.A. et al, Risk of thromboembolic events in controlled trials of rFVIIa in spontaneous intracerebral hemorrhage. Stroke. 2008;39:850–856.
  11. [11]Antihypertensive treatment of acute cerebral hemorrhage. Crit Care Med. 2010;38:637–648.
  12. [12]Arruda, W.O., de Lacerda Junior, F.S. Electrocardiographic findings in acute cerebrovascular hemorrhage. A prospective study of 70 patients. Arq Neuropsiquiatr. 1992;50:269–274.
  13. [13]Christensen, H., Fogh Christensen, A., Boysen, G. Abnormalities on ECG and telemetry predict stroke outcome at 3 months. J Neurol Sci. 2005;234:99–103.
  14. [14]Dimant, J., Grob, D. Electrocardiographic changes and myocardial damage in patients with acute cerebrovascular accidents. Stroke. 1977;8:448–455.
  15. [15]Goldstein, D.S. The electrocardiogram in stroke: relationship to pathophysiological type and comparison with prior tracings. Stroke. 1979;10:253–259.
  16. [16]Huang, C.H., Chen, W.J., Chang, W.T. et al, QTc dispersion as a prognostic factor in intracerebral hemorrhage. Am J Emerg Med. 2004;22:141–144.
  17. [17]Khechinashvili, G., Asplund, K. Electrocardiographic changes in patients with acute stroke: a systematic review. Cerebrovasc Dis. 2002;14:67–76.
  18. [18]Myers, M.G., Norris, J.W., Hachinski, V.C. et al, Cardiac sequelae of acute stroke. Stroke. 1982;13:838–842.
  19. [19]Yamour, B.J., Sridharan, M.R., Rice, J.F. et al, Electrocardiographic changes in cerebrovascular hemorrhage. Am Heart J. 1980;99:294–300.
  20. [20]Maramattom, B.V., Manno, E.M., Fulgham, J.R. et al, Clinical importance of cardiac troponin release and cardiac abnormalities in patients with supratentorial cerebral hemorrhages. Mayo Clin Proc. 2006;81:192–196.
  21. [21]Meyer, J.S., Stoica, E., Pascu, I. et al, Catecholamine concentrations in CSF and plasma of patients with cerebral infarction and haemorrhage. Brain. 1973;96:277–288.
  22. [22]Myers, M.G., Norris, J.W., Hachniski, V.C. et al, Plasma norepinephrine in stroke. Stroke. 1981;12:200–204.
  23. [23]Goldstein, J.N., Thomas, S.H., Frontiero, V. et al, Timing of fresh frozen plasma administration and rapid correction of coagulopathy in warfarin-related intracerebral hemorrhage. Stroke. 2006;37:151–155.
  24. [24]Rosand, J., Eckman, M.H., Knudsen, K.A. et al, The effect of warfarin and intensity of anticoagulation on outcome of intracerebral hemorrhage. Arch Intern Med. 2004;164:880–884.
  25. [25]O'Donnell, H.C., Rosand, J., Knudsen, K.A. et al, Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage. N Engl J Med. 2000;342:240–245.
  26. [26]Aviles, R.J., Askari, A.T., Lindahl, B. et al, Troponin T levels in patients with acute coronary syndromes, with or without renal dysfunction. N Engl J Med. 2002;346:2047–2052.
  27. [27]Thygesen, K., Alpert, J.S., White, H.D. Universal definition of myocardial infarction. J Am Coll Cardiol. 2007;50:2173–2195.
  28. [28]Apple, F.S., Wu, A.H., Jaffe, A.S. European Society of Cardiology and American College of Cardiology guidelines for redefinition of myocardial infarction: how to use existing assays clinically and for clinical trials. Am Heart J. 2002;144:981–986.
  29. [29]FitzMaurice, E., Wendell, L., Snider, R. et al, Effect of statins on intracerebral hemorrhage outcome and recurrence. Stroke. 2008;39:2151–2154.
  30. [30]Byer, E., Ashman, R., Toth, L. Electrocardiogram with large upright T waves and log Q-T intervals. Am Heart J. 1947;:796–799.
  31. [31]Bozluolcay, M., Ince, B., Celik, Y. et al, Electrocardiographic findings and prognosis in ischemic stroke. Neurol India. 2003;51:500–502.
  32. [32]Calder, K. QTc dispersion in intracerebral hemorrhage. Am J Emerg Med. 2005;23:98.
  33. [33]Catanzaro, J.N., Meraj, P.M., Zheng, S. et al, Electrocardiographic T-wave changes underlying acute cardiac and cerebral events. Am J Emerg Med. 2008;26:716–720.
  34. [34]Davis, T.P., Alexander, J., Lesch, M. Electrocardiographic changes associated with acute cerebrovascular disease: a clinical review. Prog Cardiovasc Dis. 1993;36:245–260.
  35. [35]Fure, B., Bruun Wyller, T., Thommessen, B. Electrocardiographic and troponin T changes in acute ischaemic stroke. J Intern Med. 2006;259:592–597.
  36. [36]Golbasi, Z., Selcoki, Y., Eraslan, T. et al, QT dispersion. Is it an independent risk factor for in-hospital mortality in patients with intracerebral hemorrhage?. Jpn Heart J. 1999;40:405–411.
  37. [37]Kawasaki, T., Azuma, A., Sawada, T. et al, Electrocardiographic score as a predictor of mortality after subarachnoid hemorrhage. Circ J. 2002;66:567–570.
  38. [38]Lanzino, G., Kongable, G.L., Kassell, N.F. Electrocardiographic abnormalities after nontraumatic subarachnoid hemorrhage. J Neurosurg Anesthesiol. 1994;6:156–162.
  39. [39]Manninen, P.H., Ayra, B., Gelb, A.W. et al, Association between electrocardiographic abnormalities and intracranial blood in patients following acute subarachnoid hemorrhage. J Neurosurg Anesthesiol. 1995;7:12–16.
  40. [40]McDermott, M.M., Lefevre, F., Arron, M. et al, ST segment depression detected by continuous electrocardiography in patients with acute ischemic stroke or transient ischemic attack. Stroke. 1994;25:1820–1824.
  41. [41]Perron, A.D., Brady, W.J. Electrocardiographic manifestations of CNS events. Am J Emerg Med. 2000;18:715–720.
  42. [42]Sakr, Y.L., Lim, N., Amaral, A.C. et al, Relation of ECG changes to neurological outcome in patients with aneurysmal subarachnoid hemorrhage. Int J Cardiol. 2004;96:369–373.
  43. [43]Tanaka, M., Nakayama, Y., Maeda, Y. et al, Electrocardiographic Q-waves as a predictor of mortality in patients with cerebral infarction. Neurology. 2004;62:1818–1821.
  44. [44]Tatschl, C., Stollberger, C., Matz, K. et al, Insular involvement is associated with QT prolongation: ECG abnormalities in patients with acute stroke. Cerebrovasc Dis. 2006;21:47–53.
  45. [45]Zaroff, J.G., Rordorf, G.A., Newell, J.B. et al, Cardiac outcome in patients with subarachnoid hemorrhage and electrocardiographic abnormalities. Neurosurgery. 1999;44:34–39 (discussion 39-40).
  46. [46]Norris, J.W., Froggatt, G.M., Hachinski, V.C. Cardiac arrhythmias in acute stroke. Stroke. 1978;9:392–396.
  47. [47]Apak, I., Iltumur, K., Tamam, Y. et al, Serum cardiac troponin T levels as an indicator of myocardial injury in ischemic and hemorrhagic stroke patients. Tohoku J Exp Med. 2005;205:93–101.
  48. [48]Hays, A., Diringer, M.N. Elevated troponin levels are associated with higher mortality following intracerebral hemorrhage. Neurology. 2006;66:1330–1334.
  49. [49]Scirica, B.M., Morrow, D.A. Troponins in acute coronary syndromes. Prog Cardiovasc Dis. 2004;47:177–188.
  50. [50]Horowitz, M.B., Willet, D., Keffer, J. The use of cardiac troponin-I (cTnI) to determine the incidence of myocardial ischemia and injury in patients with aneurysmal and presumed aneurysmal subarachnoid hemorrhage. Acta Neurochir (Wien). 1998;140:87–93.
  51. [51]Deibert, E., Barzilai, B., Braverman, A.C. et al, Clinical significance of elevated troponin I levels in patients with nontraumatic subarachnoid hemorrhage. J Neurosurg. 2003;98:741–746.
  52. [52]Parekh, N., Venkatesh, B., Cross, D. et al, Cardiac troponin I predicts myocardial dysfunction in aneurysmal subarachnoid hemorrhage. J Am Coll Cardiol. 2000;36:1328–1335.
  53. [53]James, P., Ellis, C.J., Whitlock, R.M. et al, Relation between troponin T concentration and mortality in patients presenting with an acute stroke: observational study. BMJ. 2000;320:1502–1504.
  54. [54]Marion, D.W., Segal, R., Thompson, M.E. Subarachnoid hemorrhage and the heart. Neurosurgery. 1986;18:101–106.
  55. [55]Kolin, A., Norris, J.W. Myocardial damage from acute cerebral lesions. Stroke. 1984;15:990–993.
  56. [56]Sato, K., Masuda, T., Izumi, T. Subarachnoid hemorrhage and myocardial damage clinical and experimental studies. Jpn Heart J. 1999;40:683–701.
  57. [57]Klouda, M.A., Brynjolfsson, G. Cardiotoxic effects of electrical stimulation of the stellate ganglia. Ann N Y Acad Sci. 1969;156:271–280.
  58. [58]Cruickshank, J.M., Neil-Dwyer, G., Lane, J. The effect of oral propranolol upon the ECG changes occurring in subarachnoid haemorrhage. Cardiovasc Res. 1975;9:236–245.
  59. [59]Offerhaus, L., van Gool, J. Electrocardiographic changes and tissue catecholamines in experimental subarachnoid haemorrhage. Cardiovasc Res. 1969;3:433–440.
  60. [60]Mertes, P.M., Carteaux, J.P., Jaboin, Y. et al, Estimation of myocardial interstitial norepinephrine release after brain death using cardiac microdialysis. Transplantation. 1994;57:371–377.
  61. [61]Mann, D.L., Kent, R.L., Parsons, B. et al, Adrenergic effects on the biology of the adult mammalian cardiocyte. Circulation. 1992;85:790–804.
  62. [62]Oppenheimer, S.M., Hachinski, V.C. The cardiac consequences of stroke. Neurol Clin. 1992;10:167–176.
  63. [63]Burch, G.E., Meyers, R., Abildskov, J.A. A new electrocardiographic pattern observed in cerebrovascular accidents. Circulation. 1954;9:719–723.
  64. [64]Alcalai, R., Planer, D., Culhaoglu, A. et al, Acute coronary syndrome vs nonspecific troponin elevation: clinical predictors and survival analysis. Arch Intern Med. 2007;167:276–281.
  65. [65]Ammann, P., Maggiorini, M., Bertel, O. et al, Troponin as a risk factor for mortality in critically ill patients without acute coronary syndromes. J Am Coll Cardiol. 2003;41:2004–2009.
  66. [66]Fromm, R.E. Jr. Cardiac troponins in the intensive care unit: common causes of increased levels and interpretation. Crit Care Med. 2007;35:584–588.
  67. [67]Lim, W., Cook, D.J., Griffith, L.E. et al, Elevated cardiac troponin levels in critically ill patients: prevalence, incidence, and outcomes. Am J Crit Care. 2006;15:280–288 (quiz 289).
  68. [68]Vidi, V., Rajesh, V., Singh, P.P. et al, Clinical characteristics of tako-tsubo cardiomyopathy. Am J Cardiol. 2009;104:578–582.

☆Presentation information: Abstract presented at SAEM Annual Meeting, Chicago, IL, May 2007.

☆☆Conflicts of Interest Disclosure: Dr Joshua N. Goldstein has received consulting fees from CSL Behring.

★This study is funded by the National Institute of Neurological Disorders and Stroke ( NIH K23NS059774 ).

© 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
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May 2012Volume 30, Issue 4, Pages 545–552