Low dose intravenous ketamine as an analgesic: A pilot study using an experimental model of acute pain
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Fig. 1
D-VAS for ketamine (□) and placebo (■)groups. At stimulus levels of 40 and 45 mA D-VAS P ≤.05.
—The “dissociative” anesthetic, ketamine, has been in wide use for more than 25 years. It induces a unique combination of sedative, amnesic, and analgesic effects without suppressing the reticular activating system. Laryngeal reflexes remain intact and cardiorespiratory function is not depressed.1,2 Use of ketamine by emergency physicians has typically been limited to brief painful procedures performed on children.3-5 It has a half-life of 7 to 11 minutes and duration of action of <1 hour after IV infusion.
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© 2001 W.B. Saunders Company. Published by Elsevier Inc. All rights reserved.
