Out-of-hospital thrombolysis in cardiac arrest after unsuccessful resuscitation Frédéric Lapostolle, Florence Pommerie, Jean Catineau, Frédéric Adnet
DOI: http://dx.doi.org/10.1053/ajem.2001.24504
The American Journal of Emergency Medicine , Vol. 19 , Issue 4 ,
Published in issue: July 2001
x Survival after sudden out-of-hospital cardiac arrest remains low.1 As suggested by Spaulding et al, acute myocardial infarction (AMI) is frequent in patients with cardiac arrest.2 Acute myocardial infarction therapies associated with advanced cardiac life support (ACLS) could improve survival. We report the case of a patient who presented sudden out-of-hospital cardiac arrest in which ACLS was unsuccessful. After a thrombolytic bolus infusion, return to spontaneous circulation suggested that thrombolytic therapy could facilitate recovery during out of hospital cardiopulmonary resuscitation as recently discussed.
Should unobstructed gasping be facilitated and confirmed before administering adrenaline, otherwise, give titrated vasopressin? Eric M. Rottenberg
DOI: http://dx.doi.org/10.1016/j.ajem.2014.10.015
The American Journal of Emergency Medicine , Vol. 33 , Issue 2 ,
Published online: October 15 2014
x A recent commentary, “Resuscitation That's (Un)Shockable: Time to Get the Adrenaline Flowing”, published in the New England Journal of Medicine Journal Watch called attention to a relatively recent study showing that a large and increasing percentage of patients with in-hospital cardiac arrests exhibit initial nonshockable rhythms (asystole or pulseless electrical activity [PEA]; 82% in 2009 vs 69% in 2000) and a most recent study that concluded that neurologically intact survival to hospital discharge after in-hospital cardiac arrest was significantly more likely after earlier epinephrine administration.
Dose-response of vasopressin in a rat model of asphyxial cardiac arrest Meng-Hua Chen, Feng-Qing Song, Lu Xie, Li-Ping Wang, Jun-Yu Lu, Xian-Wei Zhang, Xiao-Fen Tian
DOI: http://dx.doi.org/10.1016/j.ajem.2008.07.031
The American Journal of Emergency Medicine , Vol. 27 , Issue 8 ,
Published in issue: October 2009
x The advantage of vasopressin over epinephrine in the treatment of cardiac arrest (CA) is still being debated, and it is not clear whether a high dose of vasopressin is beneficial or detrimental during or after cardiopulmonary resuscitation (CPR) in a rat model of CA. In this study, asphyxial CA was induced in 40 male Sprague-Dawley rats. After 10 minutes of asphyxia, CPR was initiated; and the effects of different doses of vasopressin (low dose, 0.4 U/kg; medium dose, 0.8 U/kg; and high dose, 2.4 U/kg; intravenous; n = 10 in each group) and a saline control (isotonic sodium chloride solution, 1 mL, intravenous) were compared.
Contents to volume 3
DOI: http://dx.doi.org/10.1016/0735-6757(85)90193-7
The American Journal of Emergency Medicine , Vol. 3 , Issue 6 ,
Published in issue: November 1985
Comparison of different doses of epinephrine on myocardial perfusion and resuscitation success during cardiopulmonary resuscitation in a pig model Karl H. Lindner, Friedrich W. Ahnefeld, Ingrid M. Bowdler
DOI: http://dx.doi.org/10.1016/0735-6757(91)90008-8
The American Journal of Emergency Medicine , Vol. 9 , Issue 1 ,
Published in issue: January 1991
x Published results of dose-response effects of adrenergic drugs (epinephrine [E]) vary so much between studies because of differences in animal models and duration of ischemia before drug administration. In this investigation the effects of different doses of E on coronary perfusion pressure (CPP), left ventricular myocardial blood flow (MBF) and resuscitation success were compared during closed-chest cardiopulmonary rest scitation (CRP) after a 4-minute period of ventricular fibrillation in 28 pigs.
Steroids in cardiac arrest: not ready for prime time? Joseph Varon, Paul E. Marik
DOI: http://dx.doi.org/10.1016/j.ajem.2006.12.023
The American Journal of Emergency Medicine , Vol. 25 , Issue 3 ,
Published in issue: March 2007
x Despite an improved understanding and management of cardiac arrest, and the widespread application of do-not-resuscitate orders in an attempt to prevent the inappropriate use of cardiopulmonary resuscitation (CPR), the success rate after inhospital cardiac arrest has remained unchanged over the last 3 decades, with return of spontaneous circulation (ROSC) in about 30% with approximately 15% of patients being discharged neurologically intact [1-7].
Comparison of NIO and EZ-IO intraosseous access devices in adult patients under resuscitation performed by paramedics: a randomized crossover manikin trial Łukasz Szarpak, Łukasz Czyzewski, Bogumiła Woloszczuk-Gebicka, Paweł Krajewski, Marcin Fudalej, Zenon Truszewski
DOI: http://dx.doi.org/10.1016/j.ajem.2016.03.017
Publication stage: In Press Corrected Proof
The American Journal of Emergency Medicine
Published online: March 8 2016
x Obtaining intravascular (IV) access is one of the key procedures during cardiopulmonary resuscitation (CPR), particularly during nondefibrillation rhythms, in which the rapid delivery of epinephrine is one of the main elements of the emergency treatment. The average time needed for peripheral IV catheterization is reported to be between 2.5 and 16 minutes in patients with difficult IV access [1]. The 2015 American Heart Association guidelines for CPR suggest that rescuers establish intraosseous (IO) access if an intravenous line is not easily obtainable [2].
The authors' response to comments Young-Min Kim, Ji-Hoon Kim, Hyung-Goo Kang, Hyun Soo Chung, Hyeon-Woo Yim, Seung-Hee Jeong
DOI: http://dx.doi.org/10.1016/j.ajem.2010.09.024
The American Journal of Emergency Medicine , Vol. 29 , Issue 1 ,
Published online: October 25 2010
x We would like to thank Dr Xue for his interest and insightful comments on our recent report [1]. We certainly agree with his 2 points that the participants in our study should not be regarded as novices to 2 video laryngoscopes (VLs) and that Macintosh laryngoscope (MAC) is generally more cost-effective than the VLs. However, in the aspect of clinical experiences, the participants' experiences in the VLs are different from the MAC. Like direct laryngoscopic intubation, clinical experiences in addition to training on manikin are required for adequate skill acquisition of indirect laryngoscopic intubation using new VLs.
CPRmeter for inexperienced layperson, bystander's friend or patient's foe? Y. Freund, A.L. Philippon, S. Carreira, A. Duguet
DOI: http://dx.doi.org/10.1016/j.ajem.2013.10.038
The American Journal of Emergency Medicine , Vol. 32 , Issue 2 ,
Published online: November 25 2013
x We read with great interest the report on the randomized crossover trial by Buléon et al [1]. As the authors highlighted, the quality of cardiopulmonary resuscitation (CPR) is a great determinant for cardiac arrest outcome. Their study reports that the use of a CPRmeter is associated with a better quality of chest compression (CC), including rhythm and depth.
An unusual complication of cardiopulmonary resuscitation: Stomach perforation Mustafa Ahmet Afacan, Sahin Colak, Harun Gunes, Hayati Kandis, Ayhan Saritas, Mustafa Cortuk, Ismet Ozaydin
DOI: http://dx.doi.org/10.1016/j.ajem.2014.02.027
The American Journal of Emergency Medicine , Vol. 32 , Issue 9 ,
Published online: February 26 2014
x Stomach perforation is an unusual complication of cardiopulmonary resuscitation. It generally occurs while providing an advanced airway. Stomach perforation may develop as a consequence of chest compressions in a patient with stomach distention caused by long periods of bag-valve mask ventilation. We presented this case to emphasize that stomach perforation may develop during cardiopulmonary resuscitation, and early diagnosis and surgical treatment may be lifesaving.
Letter in response to: Therapeutic hypothermia after cardiac arrest caused by self-inflicted intoxication: a multicenter retrospective cohort study Denise Fernández, Mark Su
DOI: http://dx.doi.org/10.1016/j.ajem.2015.01.045
The American Journal of Emergency Medicine , Vol. 33 , Issue 4 ,
Published online: February 6 2015
x We read with great interest the study by Kim et al on the potential benefits of therapeutic hypothermia (TH) in the treatment of intentional overdoses
[1]. Based on the findings of this study, the authors conclude that poisoned patients with out-of-hospital cardiac arrest (OHCA) treated with TH have higher survival-to-discharge rates. We commend the authors for studying the effects of this therapy on poisoned patients because literature on interventions for poisoning-induced OHCA is uncommon. However, we have reservations regarding their interpretation of the results.
The contribution of left ventricular stroke volume to CPR blood flow depends upon the duty cycle : M. J. Hausknecht, R. Brower, R. Wise, S. Permutt. Johns Hopkins Medical Institutions. Baltimore, MD 21205
DOI: http://dx.doi.org/10.1016/0735-6757(84)90142-6
The American Journal of Emergency Medicine , Vol. 2 , Issue 4 ,
Published in issue: July 1984
Abdominal oxygen saturation for monitoring return of spontaneous circulation in out-of-hospital cardiac arrest using near infrared spectrophometry Asim Kalkan, Ozlem Bilir, Gokhan Ersunan, Deniz Ozel, Mahmut Tas, Mehmet Erdem Memetoglu
DOI: http://dx.doi.org/10.1016/j.ajem.2014.11.029
The American Journal of Emergency Medicine , Vol. 33 , Issue 3 ,
Published online: November 28 2014
x We used near-infrared spectrophotometry to assess the initial and final abdominal and cerebral saturations during cardiopulmonary resuscitation (CPR) of patients with out-of-hospital cardiac arrest to determine if there is a correlation between increase in these saturation values and return of spontaneous circulation.
Effect of allopurinol and dimethylsulfoxide on long-term survival in rats after cardiorespiratory arrest and resuscitation Stephen F. Badylak, Charles F. Babbs, Constantina Kougias, Kari Blaho
DOI: http://dx.doi.org/10.1016/0735-6757(86)90299-8
The American Journal of Emergency Medicine , Vol. 4 , Issue 4 ,
Published in issue: July 1986
x The effects of allopurinol and dimethylsulfoxide (DMSO) upon reperfusion injury were tested in separate studies that utilized a rat model of cardiorespiratory arrest and resuscitation. The rats were subjected to 7 minutes of arrest followed by resuscitation, and then were alternately assigned to either a drug-treated group or a vehicle-treated group (n = 22 for all groups). Drug treatment was given after the return of spontaneous circulation, and survival was monitored for a ten-day period. Study 1 utilized DMSO (50% solution, 1 ml/kg) as the test drug and saline solution as the vehicle.
Problems with prehospital cardiac resuscitation: The two-rescuer response Neal Robert Abarbanell
DOI: http://dx.doi.org/10.1016/0735-6757(92)90055-3
The American Journal of Emergency Medicine , Vol. 10 , Issue 2 ,
Published in issue: March 1992
Motion analysis of cardiopulmonary resuscitation Nathalie Fournier, Yves Godio-Raboutet, Maxime Llari, Harold N. Ibouanga-Kipoutou, Pierre-Jean Arnoux, Michel Behr, Salah Boussen
DOI: http://dx.doi.org/10.1016/j.ajem.2015.07.051
The American Journal of Emergency Medicine , Vol. 33 , Issue 10 ,
Published online: July 28 2015
x Some cardiopulmonary resuscitation (CPR) monitoring devices were released in recent years. Some of them are motion sensors. There are no guidelines were to position future or present sensors during CPR. We evaluate the possible influence of the location of motion sensors by a high-speed camera during a CPR on a manikin.
Continuous chest compressions improve survival and neurologic outcome in a swine model of prolonged ventricular fibrillation Theodoros Xanthos, Theodoros Karatzas, Konstantinos Stroumpoulis, Pavlos Lelovas, Panagiotis Simitsis, Ioannis Vlachos, Grigorios Kouraklis, Evangelia Kouskouni, and others
DOI: http://dx.doi.org/10.1016/j.ajem.2011.10.008
The American Journal of Emergency Medicine , Vol. 30 , Issue 8 ,
Published online: December 28 2011
x Evidence suggests that any interruptions, including those of rescue breaths, during cardiopulmonary resuscitation (CPR) have significant, detrimental effects on survival. The 2010 International Liaison Committee on Resuscitation guidelines strongly emphasized on the importance of minimizing interruptions during chest compressions. However, those guidelines also stress the need for ventilations in the case of prolonged cardiac arrest (CA), and it is not at present clear at which point of CA the necessity of providing ventilations overcomes the hemodynamic compromise caused by chest compressions' interruption.
An experimental study of cerebrocardiopulmonary resuscitation (CCPR) in dogs using hemodialysis : Koshimizu K. Jpn J Acute Med 1986; 10(11): 1591–1602
DOI: http://dx.doi.org/10.1016/0735-6757(87)90330-5
The American Journal of Emergency Medicine , Vol. 5 , Issue 3 ,
Published in issue: May 1987
Problems in the treatment of tetanus as indicated by an analysis of 32 autopsy cases : Honma R. Jpn J Acute Med 1986; 10(11): 1603–1616
DOI: http://dx.doi.org/10.1016/0735-6757(87)90331-7
The American Journal of Emergency Medicine , Vol. 5 , Issue 3 ,
Published in issue: May 1987
Clinical course of near-drowning victims : Kan K, Shibuya M, Nazaki H, et al. Jpn J Acute Med 1986; 10(11): 1619–1623
DOI: http://dx.doi.org/10.1016/0735-6757(87)90332-9
The American Journal of Emergency Medicine , Vol. 5 , Issue 3 ,
Published in issue: May 1987
